:root{--bg:#f5f2eb;--bg-card:#fff;--bg-soft:#efebe2;--accent:#2e7b75;--accent-dark:#246b66;--accent-light:#e3eeec;--text:#2c2e2d;--text-secondary:#5c6360;--text-muted:#8a8f8c;--border:#00000014;--border-strong:#00000026;--caution-bg:#fbf4e6;--caution-border:#e5c685;--caution-text:#7a5a1b;--warning-bg:#fbede7;--warning-border:#d89e83;--warning-text:#8b3d1f;--font-sans:"Inter", system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, sans-serif;--font-serif:"Inter", system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, sans-serif;--radius-sm:6px;--radius-md:10px;--radius-lg:14px;--max-w:1080px;--max-w-narrow:760px}*{box-sizing:border-box}html,body{background:var(--bg);color:var(--text);font-family:var(--font-sans);-webkit-font-smoothing:antialiased;margin:0;padding:0;font-size:17px;line-height:1.65}a{color:var(--accent);text-decoration:none}a:hover{text-decoration:underline}h1,h2,h3,h4{color:var(--text);margin:0 0 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var(--border);margin-top:80px;padding:56px 0 32px}.footer h4{font-family:var(--font-sans);letter-spacing:.3px;text-transform:uppercase;margin:0 0 12px;font-size:14px;font-weight:600}.footer-cols{grid-template-columns:2fr 1fr 1fr 1fr;gap:40px;margin-bottom:40px;display:grid}.footer-cols ul{margin:0;padding:0;list-style:none}.footer-cols li{margin-bottom:8px}.footer-cols .nav-link{color:var(--text-secondary);background:0 0;padding:0;font-size:14px}.footer-cols .nav-link:hover{color:var(--accent);background:0 0;text-decoration:underline}.footer-cta-btn{background:var(--accent);border-radius:var(--radius-sm);cursor:pointer;margin-top:4px;padding:9px 18px;font-size:14px;font-weight:500;text-decoration:none;transition:background .15s;display:inline-block;color:#fff!important}.footer-cta-btn:hover{background:var(--accent-dark);text-decoration:none;color:#fff!important}.footer-tag{color:var(--text-secondary);max-width:360px;margin:0;font-size:14px;line-height:1.6}.footer-legal{border-top:.5px 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20px;overflow:hidden}.disclaimer-toggle{text-align:left;cursor:pointer;width:100%;color:inherit;background:0 0;border:none;justify-content:space-between;align-items:flex-start;gap:12px;min-height:48px;padding:14px 16px;font-size:14px;line-height:1.5;display:flex}.disclaimer-preview{opacity:.9;font-weight:400}.disclaimer-chevron{background:#0000000f;border-radius:50%;flex-shrink:0;justify-content:center;align-items:center;width:28px;height:28px;font-size:18px;line-height:1;display:inline-flex}.disclaimer-body{padding:0 16px 16px;font-size:14px;line-height:1.55}.disclaimer-body p{margin:0 0 10px}.disclaimer-links{font-size:13px;margin-bottom:0!important}.protocol-sticky{z-index:40;background:color-mix(in srgb, var(--bg) 92%, transparent);-webkit-backdrop-filter:blur(10px);border-bottom:.5px solid var(--border);margin:0 -16px 8px;padding:10px 16px 12px;position:sticky;top:56px}@supports not ((-webkit-backdrop-filter:blur(10px)) or (backdrop-filter:blur(10px))){.protocol-sticky{background:var(--bg)}}.protocol-filter-grid{grid-template-columns:1fr;gap:10px;display:grid}.filter-field{flex-direction:column;gap:4px;margin:0;display:flex}.filter-label{letter-spacing:.3px;text-transform:uppercase;color:var(--text-muted);font-size:12px;font-weight:600}.protocol-filter-grid select,.protocol-filter-grid input[type=search]{background:var(--bg-card);border:1px solid var(--border-strong);border-radius:var(--radius-md);width:100%;color:var(--text);appearance:none;min-height:48px;padding:12px 14px;font-size:16px}.protocol-filter-grid select{background-image:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='12' height='8' viewBox='0 0 12 8'%3E%3Cpath fill='%235C6360' d='M1 1l5 5 5-5'/%3E%3C/svg%3E");background-position:right 14px center;background-repeat:no-repeat;padding-right:36px}.protocol-filter-grid input[type=search]:focus,.protocol-filter-grid select:focus{border-color:var(--accent);box-shadow:0 0 0 3px var(--accent-light);outline:none}.type-chip-scroll{-webkit-overflow-scrolling:touch;scrollbar-width:none;overscroll-behavior-x:contain;gap:8px;margin:10px 0 0;padding:2px 0 6px;display:flex;overflow-x:auto}.type-chip-scroll::-webkit-scrollbar{display:none}.type-chip{background:var(--bg-card);border:1px solid var(--border);cursor:pointer;color:var(--text-secondary);white-space:nowrap;border-radius:999px;flex:none;align-items:center;gap:6px;min-height:40px;padding:10px 14px;font-size:13px;font-weight:500;display:inline-flex}.type-chip .chip-count{background:var(--bg-soft);color:var(--text-muted);border-radius:999px;padding:1px 7px;font-size:11px;font-weight:600}.type-chip.active{background:var(--accent);border-color:var(--accent);color:#fff}.type-chip.active 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10px;padding-top:4px;padding-bottom:6px;scroll-margin-top:170px;font-size:15px;font-weight:700}.protocol-group:first-child .letter-heading{margin-top:8px}.protocol-card{background:var(--bg-card);border:.5px solid var(--border);border-radius:var(--radius-lg);margin-bottom:12px;padding:18px 16px;overflow:hidden}.protocol-card-head{flex-wrap:wrap;align-items:flex-start;gap:8px 10px;margin-bottom:14px;display:flex}.protocol-title{word-wrap:break-word;flex:auto;min-width:0;margin:0;font-size:18px;font-weight:600;line-height:1.3}.stage-badge{background:var(--accent-light);color:var(--accent-dark);word-break:break-word;border-radius:999px;max-width:100%;padding:5px 10px;font-size:12px;font-weight:600;line-height:1.3;display:inline-block}.stage-badge-muted{background:var(--bg-soft);color:var(--text-muted);font-weight:500}.dose-table{border:1px solid var(--border);border-radius:var(--radius-md);flex-direction:column;gap:0;margin:0 0 14px;display:flex;overflow:hidden}.dose-row{background:var(--bg-card);border-top:1px solid var(--border);grid-template-columns:1fr;gap:2px 12px;padding:10px 12px;font-size:14px;line-height:1.4;display:grid}.dose-row:first-child{border-top:none}.dose-row:nth-child(2n){background:var(--bg-soft)}.drug-name{color:var(--text);font-weight:600}.drug-dose{color:var(--accent-dark);font-variant-numeric:tabular-nums;font-weight:600}.drug-sched{color:var(--text-muted);font-size:13px}.protocol-notes{color:var(--text-secondary);white-space:pre-wrap;overflow-wrap:anywhere;margin:0 0 12px;font-size:14px;line-height:1.55}.protocol-uncertainty{background:var(--caution-bg);border:1px solid var(--caution-border);color:var(--caution-text);border-radius:var(--radius-sm);align-items:flex-start;gap:8px;margin:0 0 12px;padding:10px 12px;font-size:13px;line-height:1.45;display:flex}.uncertainty-label{letter-spacing:.4px;text-transform:uppercase;background:#0000000f;border-radius:4px;flex-shrink:0;padding:2px 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#0000002e}.back-to-top:hover{background:var(--accent-dark)}.protocols-cta-card{border-left:4px solid var(--accent)}@media (width>=640px){.protocols-inner{padding-top:40px}.protocols-intro{font-size:17px}.protocol-sticky{border-radius:0 0 var(--radius-md) var(--radius-md);margin:0 -8px 12px;padding:12px 8px 14px}.protocol-filter-grid{grid-template-columns:minmax(0,1.1fr) minmax(0,1fr);gap:12px}.protocol-card{padding:22px}.protocol-title{font-size:20px}.dose-row{grid-template-columns:minmax(110px,1.1fr) minmax(100px,1fr) minmax(0,1.4fr);align-items:baseline}.protocol-sources{flex-flow:wrap}.source-link{justify-content:flex-start;width:auto}}@media (width<=639px){.container-narrow.protocols-inner,.protocols-inner.container-narrow{padding-left:16px;padding-right:16px}.protocols-inner h1{margin-bottom:8px;font-size:26px}.page.protocols-inner{padding-top:24px}}@media 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